张家祥，男，中共党员，医学博士，副教授，硕士生导师，英国萨里大学访问学者。兼任中国环境诱变剂学会生物标志物专业委员会青年委员，安徽省环境诱变剂学会常务理事，安徽省预防医学会职业卫生与职业病专业委员会常务委员，安徽省医师协会变态反应医师分会常务委员，安徽省职业健康安全协会职业卫生与放射卫生分会委员。

主持国家自然科学基金项目2项，安徽省自然科学基金青年项目、教育部重点实验室开放课题重点项目等省部级课题多项，主持省质量工程项目教学项目3项，在国内外期刊发表学术论文60余篇，获安徽省科学技术奖1项，ylzzcom永利总站线路检测2023年度优秀教师，ylzzcom永利总站线路检测2022年復元科技新星，ylzzcom永利总站线路检测2018年度科技新星称号，参编安徽大学出版社《预防保健学》（第3、4版）兼任编委会秘书。

主要研究和招生方向：职业性有害因素暴露与免疫损伤

联系邮箱：jiaxiang5337@126.com

一、承担课题

1. 主持的科研项目

[1] 国家自然科学基金项目，82273602，2023.01-2026.12，主持

[2] 国家自然科学基金项目，81502791，2016.01-2018.12，主持

[3] 安徽省自然科学基金项目，2008085QH385，2020.07-2022.06，主持

2. 主持和参与的教研项目

[1] 空气理化检验线上课程（原MOOC）（2020mooc198），省级质量工程项目，主持

[2] 基于OKR评估方法的《职业卫生与职业医学》教学模式探究（2021jyxm0676），省级质量工程项目，主持

[3] 医疗卫生人员职业卫生与防护（xjmooc31），校级大规模在线开放课程（MOOC）示范项目，参与人

[4] 空气理化检验（xjzxkfkc51），校级大规模在线开放课程（MOOC）示范项目，参与人

3. 其他  

[1] 安徽省教育工委安徽省教育厅中青年教师培养行动项目，2024年  

[2] ylzzcom永利总站线路检测青年英才“双培工程”，2024年

二、近5年代表性论文

[1] Jia X, Zhu L, Zhu Q*, Zhang J*. The role of mitochondrial dysfunction in kidney injury and disease. Autoimmun Rev. 2024, 21; 23(6):103576. (中科院一区，IF:9.2)

[2] Zhu L, Jia X, Xie H, Zhang J*, Zhu Q*. Trichloroethylene exposure, multi-organ injury, and potential mechanisms: A narrative review. Sci Total Environ. 2024; 946:174029. (中科院一区，IF:8.2)

[3] Gao L#, Zuo XL#, Dong LL, Zhou SF, Wang ZJ, Duan YS, Chen MY, Zhu QX*, Zhang JX*. Hepatocyte mitochondrial DNA mediates macrophage immune response in liver injury induced by trichloroethylene. Ecotoxicol Environ Saf. 2024; 276:116317. (中科院一区，IF:6.2)

[4] Zuo X#, Gao L#, Peng X, Dong L, Huang M, Hu T, Deng L*, Zhu Q*, Zhang J*. Unveiling the role of mtDNA in Liver-Kidney Crosstalk: Insights from trichloroethylene hypersensitivity syndrome. Int Immunopharmacol. 2024; 138:112513. (IF:4.8)

[5] Zhang J#, Huang H#, Ding B, Liu Z, Chen D, Li S, Shen T*, Zhu Q*. Histone demethylase KDM4A mediating macrophage polarization: A potential mechanism of trichloroethylene induced liver injury. Cell Biol Int. 2024; 48(8):1148-1159. (IF:3.3)

[6] Xu Y, Chu C, Shi Z, Zhang J*. The role of hepatocyte mitochondrial DNA in liver injury. Biomed Pharmacother. 2023; 168:115692. (中科院一区，IF:6.9)

[7] Ding B#, Zhou S#, Wang Z#, Liu W, Gao L, Ding Y, Huang H, Zhu Q*, Zhang JX*. Macrophage autophagy contributes to immune liver injury in trichloroethylene sensitized mice: Critical role of TNF-α mediating mTOR pathway. J Cell Physiol. 2023; 238(10):2267-2281. (IF:4.5)

[8] Liu Z#, Ma J#, Zuo X, Zhang X, Xie H, Wang F, Wu C, Zhang J*, Zhu Q*. IP3R-dependent mitochondrial dysfunction mediates C5b-9-induced ferroptosis in trichloroethylene-caused immune kidney injury. Front Immunol. 2023; 14:1106693. (IF:5.7)

[9] Zhou SF#, Xu QY#, Yang Y, Xie HB, Zhang JX*, Zhu QX*. The role of Kupffer cell activation in immune liver damage induced by trichloroethylene associated with the IFN-γ/STAT1 signaling pathway. Toxicol Ind Health. 2023 39(9):515-527. (IF:1.7)

[10] Ma J#, Liu Z#, Zhou S, Chen M, Gao L, Zuo X, Zhang X, Zhang J*, Zhu Q*. Renal tubular in TCE-sensitization-induced immune kidney injury: Role of mitochondrial DNA in activating the cGAS-STING signaling pathway. Int Immunopharmacol. 2022; 113:109432. (IF:4.8)

[11] Xie H#, Peng J#, Zhang X, Deng L, Ding Y, Zuo X, Wang F, Wu Y, Zhang J*, Zhu Q*. Effects of mitochondrial reactive oxygen species-induced NLRP3 inflammasome activation on trichloroethylene-mediated kidney immune injury. Ecotoxicol Environ Saf. 2022, 244:114067. (中科院一区，IF:6.2)

[12] Zhang X#, Duan Y#, Ma J, Liu Z, Ding Y, Xie H, Peng J, Wang F, Zhang J*, Zhu Q*. Trichloroethylene induces immune renal tubular injury through SIRT 1/HSP 70/TLR 4 pathway in BALBc mice. Int Immunopharmacol. 2022; 112:109203. (IF:4.8)

[13] Liu Z, Ma J, Zuo X, Zhang X, Hong Y, Cai S, Huang H, Wang F, Wu C, Zhang J*, Zhu Q*. C5b-9 mediates ferroptosis of tubular epithelial cells in trichloroethylene-sensitization mice. Ecotoxicol Environ Saf. 2022; 244:114020. (中科院一区，IF:6.2)

[14] Zuo X#, Liu Z#, Ma J, Ding Y, Cai S, Wu C, Zhang J*, Zhu Q*. Wnt 5a mediated inflammatory injury of renal tubular epithelial cells dependent on calcium signaling pathway in Trichloroethylene sensitized mice. Ecotoxicol Environ Saf. 2022; 243:114019. (中科院一区，IF:6.2)

[15] Liu ZY, Jiang HZ, Wang L, Chen MX, Wang HT, Zhang JX*. Diagnostic accuracy of red blood cell distribution width for neonatal sepsis. Minerva Pediatr (Torino). 2022; 74(2):202-212. (IF:1.0)

[16] Xie H#, Zhang X#, Peng J#, Deng L, Wang F, Zhang J*, Zhu Q*. Endothelin-1 down-regulated vascular endothelial growth factor A is involved in trichloroethene-induced kidney injury. Toxicol Ind Health. 2022; 38(5):287-298. (IF:1.7)

[17] Liang B#, Huang H#, Zhang J#, Chen G, Kong X, Zhu M, Wang P, Tang L. Case Report: Chanarin-Dorfman Syndrome: A Novel Homozygous Mutation in ABHD5 Gene in a Chinese Case and Genotype-Phenotype Correlation Analysis. Front Genet. 2022; 13:847321. (IF:2.8)

[18] 丁百旺, 黄华, 杨呓, 丁雅妮, 朱启星*, 张家祥*. TNF-α/TNFR1抑制M1型Kupffer细胞自噬在三氯乙烯致敏小鼠肝损伤中的作用.中华劳动卫生职业病杂志,2022,40(05):321-327.

[19] 黄华, 丁百旺, 左绪磊, 杨呓, 彭家乐, 王燚灿, 张家祥*, 朱启星*. 经口暴露三氯乙烯对小鼠肝脏JMJD3表达和M1型库普弗细胞极化的影响.环境与职业医学,2022,39(01):65-70.

[20] Zhang J#, Yang Y#, Huang H#, Xie HB, Huang M, Jiang W, Ding BW, Zhu QX*. TNF-α/TNFR1 regulates the polarization of Kupffer cells to mediate trichloroethylene-induced liver injury. Ecotoxicol Environ Saf. 2021; 230:113141. (中科院一区，IF:6.2)

[21] Zhang X#, Luo M#, Zhang J#, Yao Z, Zhu J, Yang S, Zhu Q, Shen T*. Carbon nanotubes promote alveolar macrophages toward M2 polarization mediated epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation. Nanotoxicology. 2021; 15(5):588-604. (IF:3.6)

[22] Xie H#, Wang H#, Wu Q, Peng J, Huang H, Wang Y, Huang M, Jiang W, Yang Y, Zhang X, Zhang J*, Zhu Q*. Endothelin-1/Endothelin Receptor Type A-Angiopoietins/Tie-2 Pathway in Regulating the Cross Talk Between Glomerular Endothelial Cells and Podocytes in Trichloroethylene-Induced Renal Immune Injury. J Inflamm Res. 2021; 14:761-776. (IF:4.2)

[23] Zhang JX#, Li N#, Xu QY, Yang Y, Xie HB, Shen T*, Zhu QX*. Kupffer cell depletion attenuates IL-6/STAT3 mediates hepatocyte apoptosis in immunological liver injury of trichloroethylene sensitized mice. Int Immunopharmacol. 2020; 88:106897. (IF:4.8)

[24] Zhang JX#, Xu QY#, Yang Y, Li N, Zhang Y, Deng LH, Zhu QX*, Shen T*. Kupffer cell inactivation ameliorates immune liver injury via TNF-α/TNFR1 signal pathway in trichloroethylene sensitized mice. Immunopharmacol Immunotoxicol. 2020; 42(6):545-555. (IF:2.9) 

[25] 刘志远,张家祥*,朱启星.职业性三氯乙烯药疹样皮炎的治疗策略[J].中国工业医学杂志, 2020, 33(04):319-322.

（#共同第一作者，*通讯作者）